New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...

Walmart+ Week is taking on Prime Day: What you need to know

UPDATE: Jun. 15, 2024, 11:35 a.m. EDT This story has been updated with the top deals from the last Walmart Plus Week in 2023. Look out for these deals and more when Walmart Plus Week returns on June 17, 2024.

As we gear up for Prime Day 2024, it’s no surprise that other retailers are, too. Walmart is joining in on the fun with its very own members-only event, Walmart+ Week, which launches June 17 to 23, 2024. If you haven’t been keeping track with how quickly June has been flying by, that’s next week.

Like Prime Day, we expect this shopping event to be jam-packed with discounts on products and services from which Walmart+ members can benefit. Here’s everything we know about the sales event so far.

What is Walmart+ Week?

In a press release on May 30, Walmart announced its members-only event. Deals and offerings are exclusive to Walmart+ members. While we expect many markdowns on products, this event will also offer extra savings on services like gas and travel.

SEE ALSO:

Prime Day 2024: When it’s happening and everything else we know so far

When is Walmart+ Week?

Walmart+ Week will run from June 17 to 23. We’re used to seeing other retailers offer summer sales events, usually in coordination with Prime Day. However, Amazon Prime Day will arrive sometime in July.

With Walmart+ arriving earlier, you won’t have the advantage of comparing prices at multiple sales events. Luckily, we’re expert deal hunters and will have our eyes peeled for the deals worth jumping on.

What to expect from Walmart+ Week

While we don’t know all of the exact products that will be on sale during Walmart+ Week, we do know the focus will be on discounted services Walmart+ members gain access to. Here are some of the deals we already know about:

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  • Double savings on fuel at Exxon & Mobil stations, saving 20 cents per gallon.

  • Earn 20% back in Walmart cash when booking flights, hotels, car rentals, and activities when purchased through Walmart+ Travel.

  • Complimentary Express Delivery: Get items on your doorstep in under two hours.

  • Three free months of Walmart+ InHome, delivering items into your home rather than the doorstep.

  • Exclusive access to new items is only available to Walmart+ members.

In its press release, Walmart also teased a «mystery offer» to be revealed on June 20. We don’t know what this offer will cover, but we will update you as soon as it is revealed.

Here are some of the top deals from Walmart+ Week 2023 that you may want to keep an eye out for again this year (scope out the deals to look out for during Prime Day 2024 to compare):

Can you shop Walmart+ Week without being a member?

Similar to Prime Day, Walmart+ Week is a members-only event. Walmart+ membership costs $98 per year or $12.95 per month, or is available for $49 a year for those on qualifying government assistance.

A Walmart+ membership gives you free standard delivery from the store, free shipping with no order minimum, fuel savings at Exxon and Mobil, streaming with Paramount+, and access to the Walmart+ Travel portal.

To hack the system, you can try out Walmart+ on a free 30-day trial. If you sign up today, you’ll have access to the Walmart+ Week savings; just make sure to cancel before the trial ends to avoid being charged.

What benefits do you get with a Walmart+ membership?

As a Walmart+ member, you’ll have access to a number of worthy perks, many of which are unrelated to your purchases at the retailer. Of course, you’ll get unlimited free delivery with all orders over $35. Beyond that, you get next-day and two-day shipping free with no minimum purchase required, with all returns fast and free as Walmart picks up the tab for you on any items you don’t like.

You’ll also get a number of discounts on things like fuel, auto care, and more, like free Paramount+ streaming, up to five free months of Apple Music, up to four months of Apple Fitness+, and two free months of Xbox Game Pass. You can also use your membership to try out YouTube Premium for three months if you’re looking to get rid of some pesky ads.

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