New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...

Spotify announces an in-house creative agency, tests generative AI voiceover ads

Spotify announced on Thursday that it’s venturing further into the ad space with its first in-house creative agency called Creative Lab, helping brands create custom marketing campaigns. It will also begin testing generative AI ads, the company said.

The launch of Creative Lab shows that Spotify is ramping up its efforts to attract advertisers to the platform. This could likely be an attractive offering for marketers, as they’ll be able to reach Spotify’s 615 million listeners. 

Additionally, Spotify is working on a new AI tool for advertisers: “Quick Audio,” which enables brands to create scripts and voiceovers using generative AI. A company spokesperson told us the tool will soon launch in Spotify Ads Managers. 

Image Credits: Spotify

A Spotify exec had earlier said the company was looking to use AI to generate host-read ads for podcasters.

Brands will be able to work with the new Creative Lab team to produce things like video and audio ads, in-app digital experiences and other interactive ad formats like call-to-action (CTA) cards, the spokesperson told TechCrunch.

“Every campaign Creative Lab touches is highly customized to each specific brand and business need,” the spokesperson said.

Spotify used client Rockstar Energy Drink as an example, which launched a “Press Play” livestreamed concert series within the music streaming app, featuring artists like British rapper Stormzy. Another beverage company, Aperol, will also be a Creative Lab client.

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