New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

Image
Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research and therape
Post a Comment

Shovel Knight is getting a sequel in a ‘new dimension’

Shovel Knight might be bouncing into 3D. Developer Yacht Club Games just announced a new mainline game in the hit series that started as a retro-inspired 2D platformer, and the studio says this new game will “launch Shovel Knight into an entirely new dimension of gaming,” according to a blog post.

If that wasn’t enough of a clue about the move to 3D, the Yacht Club Games’ Friday livestream celebrating the 10th anniversary of Shovel Knight featured an even more pointed hint: a 3D version of the Yacht Club Games logo.

The studio is staying mum about many specifics — there’s no release window — but did tease that “the game will bring electrifying action, richer mechanics, and all the timeless charm you expect from a Shovel Knight title.”

While you wait for that new game, Yacht Club Games will have a lot of new things you can play. The studio also announced Shovel Knight: Shovel of Hope DX, the “definitive edition” of the original Shovel Knight title that adds things like online multiplayer, stereoscopic 3D, a rewind power, in-game cheats, and the ability to play as 20 different Shovel Knight characters. Yacht Club Games says the game is “coming soon.” Shovel Knight Dig and Shovel Knight Pocket Dungeon are also getting free DLC this summer.

The developer also shared new footage of Mina the Hollower, its upcoming game that looks to be heavily inspired by the Game Boy classic The Legend of Zelda: Link’s Awakening. Mina also has a vague “coming soon” launch date, and I look forward to a more specific release window — the game looks fantastic.

Comments

Post a Comment

Popular posts from this blog

New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

Image
Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research and therape
Read more

New catalyst brings commercial high-efficiency zinc-air batteries closer to reality

Image
The upper-left schematic illustrates the flow of a zinc-air battery (ZAB). The iron-cobalt-nickel (Fe-Co-Ni) electrocatalyst (upper right) speeds both the charging and discharging of the ZAB compared to binary metal electrocatalysts or noble metals platinum and ruthenium, which occurs through the oxygen evolution reaction and oxygen reduction reaction, respectively. The diagram in the lower left illustrates the assembly of the ZAB with a flexible solid-state carbon dot/polyvinyl alcohol (CD/PVA) electrolyte that is ideal for wearable technologies. The lower-right panel shows the ZAB with the ternary Fe-Co-Ni electrocatalyst charging a cell phone. Credit: Nano Research Energy, Tsinghua University Press The effective conversion from fossil fuel-based to renewable energy sources requires cost-efficient, high-capacity, rechargeable batteries. Zinc-air batteries (ZAB) can theoretically store large amounts of energy, but current technologies require th
Read more

Biologists find nanoplastics in developing chicken heart

Image
A picture of a chicken heart with fluorescent nanoplastics. Credits: Wang et al (2024) Nanoplastics can accumulate in developing hearts, according to a study published in Environment International by biologist Meiru Wang from Leiden University. Her research on chicken embryos sheds new light on how these tiny plastic particles pose a threat to our health. Disposable cups, plastic bags and packaging material: Plastics exposed to the elements become brittle over time, and start shedding small particles from their surface into nature. These particles can be as tiny as only a few nanometers in size. You can find these nanoplastics everywhere now: in the sea, in the soil, in the food chain.… «And in our blood,» says Wang. «Nanoplastics have even been found in human placentas.» This prompted Wang to think: What happens when those nanoplastics end up in the blood of the embryo? «During an earlier study, we discovered that a high concentration
Read more