New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research and therape

Philips Hue’s jaunty sunrise smart lamp is called the Twilight

Philips Hue’s next smart bedside lamp will reportedly be called the “Twilight.” The lamp will feature two buttons on top for power, scene selection, and sleep automation, and it also has LEDs in the back that will feature a sunrise or sunset effect, according to HueBlog.com.

The rear LED and main light, like the Hue Dymera’s top and bottom lights, will apparently be individually controllable, and when triggering its sleep automation, the site says it will simulate a sunset before turning off. It’s not clear yet when — or for how much — Philips will release the Twilight.

Philips might also have a new 5-meter (about 16 feet) lightstrip called the Hue Solo on the way, as it was briefly listed by “a major American retailer” for $89.99 before being taken down, according to a story HueBlog published yesterday. And there is indeed a cached Best Buy Hue Solo product page that describes a “seamless blend of multicolor light in a single LED strip” and says it can be controlled via Bluetooth.

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