New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...

NYT's The Mini crossword answers for June 15

The Mini is a bite-sized version of The New York Times‘ revered daily crossword. While the crossword is a lengthier experience that requires both knowledge and patience to complete, The Mini is an entirely different vibe.

With only a handful of clues to answer, the daily puzzle doubles as a speed-running test for many who play it.

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So, when a tricky clue disrupts a player’s flow, it can be frustrating! If you find yourself stumped playing The Mini — much like with Wordle and Connections — we have you covered.

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NYT Connections today: See hints and answers for June 15

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‘Wordle’ today: Here’s the answer hints for June 15

Here are the clues and answers to NYT’s The Mini for Saturday, June 15, 2024:

Across

«Jack ___ could eat no fat …»

Attached with string

One who’s wise beyond their years

Sports org. with an «octagon»

___-Magnon (early human)

Olympic powerhouse in women’s gymnastics

For mature audiences, movie-wise

Put clothes on

Down

Dark beer choice

Steal

Soccer penalty awarded for coughing at another player(!) during the pandemic

Streaming interruptions

«OMG, look at this baby hedgehog!»

Hospital staffers

Units of laundry

Month when International Women’s Day is celebrated: Abbr.

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