Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
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New tech could give individuals increased control over their own
exposure to harmful gases
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Credit: University of Melbourne
In an increasingly health-conscious society, data is a hot commodity. Tracking step counts with an old-school pedometer has turned into monitoring heart rates, sleep cycles and blood oxygen levels with wearable fitness trackers, a market that has exploded in recent years. But one critical aspect of health monitoring has yet to become mainstream, because continuous air quality data is currently tied to spaces and not people.
Physicists at the ARC Center of Excellence for Transformative Meta-Optical Systems are working to address the challenge of consumer access to air quality data with the development of a portable infrared micro-spectrometer that could one day be integrated into wearable devices to monitor multiple toxic and greenhouse gases, giving individuals increased control over their own exposure to harmful gases so they can make better-informed decisions about their health.
This new technology, developed by the Center’s University of Melbourne team and published in Microsystems and Nanoengineering, uses a machine learning algorithm and metasurface spectral filter arrays to create a microspectrometer (MIMM) that detects the unique infrared signature of multiple gases using one sensor. The prototype is currently the size of a matchbox but has the potential to be miniaturized far further.
Traditional infrared spectrometers are exceptional gas detectors but are bulky equipment usually only found in laboratories. Current portable multi-gas detectors that can be purchased and used in homes and office buildings are made of multiple bulk sensor systems in one housing, increasing the size and weight of the device, limiting their usefulness.
They also use chemiresistors rather than spectroscopy, which provides inferior results and limits their lifespan. There is no path forward for the miniaturization of either of these two devices using traditional optical components and thus current technology will never be wearable or integrated into the Internet of Things.
A metasurface filter integrated with an off-the-shelf IR detector, on the other hand, addresses the issues of miniaturization by creating sensors from materials that are only nanometers thick. In this case, TMOS researchers created a metasurface spectral filter array to create a sensor with the potential to sense all harmful gases. The filter array consists of metallic nanostructures on top of a silicon substrate.
Specifically, by varying the periodicity of the nanostructures, the spectral features of these filters can be tuned to the wavelength of interest. In this study, they demonstrated its effectiveness with carbon dioxide, methane, ammonia and methyl-ethyl-ketone.
Lead author Jiajun Meng says, «The microspectrometer is a metasurface filter array integrated with a commercial IR camera that is consumable-free, compact (~ 1 cm3) and lightweight (~1 g). The machine learning algorithm is trained to analyze the data from the microspectrometer and predict the gases present.»
TMOS Chief Investigator Kenneth Crozier says, «The next steps in the research are to increase the sensitivity of the device and make the platform more robust. We are excited about this technology because, with a little more development, it can be applied to lots of other chemical detection problems (e.g. solids and liquids).»
More information: Jiajun Meng et al, Smart mid-infrared metasurface microspectrometer gas sensing system, Microsystems & Nanoengineering (2024). DOI: 10.1038/s41378-024-00697-2
Provided by ARC Centre of Excellence for Transformative Meta-Optical Systems (TMOS)
Citation: New tech could give individuals increased control over their own exposure to harmful gases (2024, June 7) retrieved 16 June 2024 from
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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
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