New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research and therape

How much does ChatGPT cost? Everything you need to know about OpenAI's pricing plans

OpenAI’s AI-powered chatbot platform ChatGPT keeps expanding with new features. It now offers a store — the GPT Store — for AI-powered applications and services. The recently introduced memories feature lets you save preferences so that chats are more tailored to you. And soon, ChatGPT will gain an upgraded voice mode, letting you interact with the platform more or less in real time.

So, you might be wondering: How much does ChatGPT cost? It’s a tougher question to answer than you might think. OpenAI offers an array of plans for ChatGPT, both paid and free, aimed at customers ranging from individuals to nonprofits, small- and medium-sized businesses, educational institutions and enterprises.

To keep track of the various ChatGPT subscription options available, we’ve put together a guide on ChatGPT pricing. We’ll keep it updated as new plans are introduced.

ChatGPT free

Once upon a time, the free version of ChatGPT was quite limited in what it could do. But that’s changed as OpenAI has rolled out new capabilities and underlying generative AI models.

ChatGPT free users get access to OpenAI’s flagship GPT-4o model, responses augmented with content from the web, access to the GPT Store and the ability to upload files and photos and ask questions about those uploads. Users can also store chat preferences as “memories” and leverage advanced data analysis, a ChatGPT feature that can “reason over” (i.e., analyze data from) files such as spreadsheets and PDFs.

There are downsides that come with the free ChatGPT plan, however, including daily capacity limits on the GPT-4o model, depending on demand. Once a user reaches the limits, they’re switched automatically — albeit temporarily — to OpenAI’s less-capable GPT-3.5 model. ChatGPT free users also miss out on certain data analysis features, which we discuss in greater detail below.

ChatGPT Plus

For individual users who want a more capable ChatGPT, there’s ChatGPT Plus, which costs $20 per month.

ChatGPT Plus offers 5x higher capacity than ChatGPT free, plus early and priority access to newer tools like OpenAI’s macOS client for ChatGPT.

In addition, ChatGPT Plus subscribers get an upgraded data analysis feature, underpinned by GPT-4o, that can create interactive charts and tables from datasets. Users can upload the files to be analyzed directly from Google Drive and Microsoft OneDrive or from their devices.

ChatGPT Team

Say you own a small business or manage an org and want more than one ChatGPT license, plus collaborative features. ChatGPT Team might fit the bill: It costs $30 per user per month or $25 per user per month billed annually for up to 149 users.

ChatGPT Team provides a dedicated workspace and admin tools for team management. All users in a ChatGPT Team plan gain access to OpenAI’s latest models and the aforementioned tools that let ChatGPT analyze, edit and extract info from files. Beyond this, ChatGPT Team lets people within a team build and share custom apps — similar to the apps in the GPT Store — based on OpenAI models. These apps can be tailored for specific use cases or departments, or tuned on a team’s data.

ChatGPT Enterprise

Large organizations — any organization in need of more than 149 ChatGPT licenses, to be specific — can opt for ChatGPT Enterprise, OpenAI’s corporate-focused ChatGPT plan. OpenAI doesn’t publish the price of ChatGPT Enterprise, but the reported cost is around $60 per user per month with a minimum of 150 users and a 12-month contract.

ChatGPT Enterprise adds “enterprise-grade” privacy and data analysis capabilities on top of the vanilla ChatGPT, as well as enhanced performance and customization options. There’s a dedicated workspace and admin console with tools to manage how employees within an organization use ChatGPT, including integrations for single sign-on, domain verification and a dashboard showing usage and engagement statistics.

Shareable conversation templates provided as a part of ChatGPT Enterprise allow users to build internal workflows and bots leveraging ChatGPT, while credits to OpenAI’s API platform let companies create fully custom ChatGPT-powered solutions if they choose.

ChatGPT Enterprise customers also get priority access to models and lines to OpenAI expertise, including a dedicated account team, training, and consolidated invoicing. And they’re eligible for Business Associate Agreements with OpenAI, which are required by U.S. law for companies that wish to use tools like ChatGPT with private health information such as medical records.

ChatGPT Edu

ChatGPT Edu, a newer offering from OpenAI, delivers a version of ChatGPT built for universities and the students attending them — as well as faculty, staff researchers and campus operations teams. Pricing hasn’t been made public or reported secondhand yet, but we’ll update this section if it is.

ChatGPT Edu is comparable to ChatGPT Enterprise with the exception that it supports SCIM, an open protocol used to simplify cloud identity and access management. (OpenAI plans to bring SCIM to ChatGPT Enterprise in the future.) As with ChatGPT Enterprise, ChatGPT Edu customers get data analysis tools, admin controls, single sign-on, enhanced security and the ability to build and share custom chatbots.

ChatGPT Edu also comes with the latest OpenAI models and, importantly, increased message limits.

OpenAI for Nonprofits

OpenAI for Nonprofits is OpenAI’s early foray into nonprofit tech solutions. It’s not a stand-alone ChatGPT plan so much as a range of discounts for eligible organizations.

Nonprofits can access ChatGPT Team at a discounted rate of $20 monthly per user. Larger nonprofits can get a 50% discount on ChatGPT Enterprise, which works out to about $30 per user.

The eligibility requirements are quite strict, however. While nonprofits based anywhere in the world can apply for discounts, OpenAI isn’t currently accepting applications from academic, medical, religious or governmental institutions.

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