Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
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Best laptop deals June 2024: Save on Apple, HP, Asus
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UPDATE: Jun. 15, 2024, 5:00 a.m. EDT This story has been updated with new laptop deals, pricing, and availability.
The very best laptop deals at a glance:
A new laptop is almost certainly a splurge, but keeping your eyes peeled for deals can make it much easier to take the leap on an upgrade. The good news is that you’ve got options at a variety of price points via Best Buy, Amazon, and beyond, whether you’re looking for an everyday workhorse, a cheap Chromebook for homework, a 2-in-1 Windows PC for drawing, or a powerful premium gaming laptop.
SEE ALSO:
Here’s when to buy a laptop, whether you need the latest specs or a great deal
Read on for our running list of the best laptop deals as of June 15. (And if you don’t see any models that check all the boxes on your spec wish list, come back soon: We add new picks every other week.)
Best laptop deal under $300
Why we like it
Asus’s ultra-portable Chromebook CM30 Detachable is one of two new non-Plus Chromebooks announced by Google last month. Best Buy has it on sale for $40 off, which is its first discount since launch.
It’s a 10.5-inch laptop/tablet hybrid that comes with a removable keyboard (hence its name), a built-in stand, a stylus, and 5MP cameras on the front and back. This particular model also features a MediaTek Kompanio 520 CPU, 4GB of memory, and 64GB of eMMC storage, which is about as basic as it gets. Still, with the included accessories, it’s a pretty good value for casual users who frequently work on the go.
Read Mashable’s full review of the HP Chromebook Plus x360 14c.
The HP Chromebook Plus x360 14c is a 14-inch ChromeOS convertible that supports Gemini AI features like «Help me write,» generative wallpapers, and Google Photos’ Magic Editor. Its dim display and noisy, low-res webcam didn’t impress Mashable tech editor Kim Gedeon when she tried it earlier this year, but «its robust aluminum chassis, flexible postures (e.g., tablet and tent modes), wide range of ports, and fantastic keyboard may leave you hooked,» she said. (It walked away with a 4/5 rating.)
The configuration with a 12th-gen Intel Core i3 CPU, 8GB of memory, and 128GB of SSD storage is marked down to just $499.99 on HP’s website, which is a 36% savings and $30 cheaper than its sale price two weeks ago.
Read Mashable’s review of the 13-inch Apple MacBook Air (M2).
Mashable Deals
The 13-inch version of Apple’s previous-gen MacBook Air won a Mashable Choice Award upon release in mid-2022, with tech and games reporter Alex Perry praising its peppy M2 processor, superb battery life, satisfying keyboard, and lightweight frame. A $170 discount at Amazon has scooted it down to a new record low of $829, which is budget laptop territory as far as MacBooks are concerned.
Read Mashable’s full review of the 15-inch Apple MacBook Air (M3).
If you think you’ll benefit from a tad more speed, extra screen real estate, support for WiFi 6E, and/or simultaneous support for two external displays, the newer 15-inch M3 MacBook Air is also on sale at an all-time low price on Amazon. The base configuration usually retails for $1,299, but you’ll pay $1,129 — another $170 in savings.
Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research an...
The upper-left schematic illustrates the flow of a zinc-air battery (ZAB). The iron-cobalt-nickel (Fe-Co-Ni) electrocatalyst (upper right) speeds both the charging and discharging of the ZAB compared to binary metal electrocatalysts or noble metals platinum and ruthenium, which occurs through the oxygen evolution reaction and oxygen reduction reaction, respectively. The diagram in the lower left illustrates the assembly of the ZAB with a flexible solid-state carbon dot/polyvinyl alcohol (CD/PVA) electrolyte that is ideal for wearable technologies. The lower-right panel shows the ZAB with the ternary Fe-Co-Ni electrocatalyst charging a cell phone. Credit: Nano Research Energy, Tsinghua University Press The effective conversion from fossil fuel-based to renewable energy sources requires cost-efficient, high-capacity, rechargeable batteries. Zinc-air batteries (ZAB) can theoretically store large amounts of energy, but current technologies require th...
A picture of a chicken heart with fluorescent nanoplastics. Credits: Wang et al (2024) Nanoplastics can accumulate in developing hearts, according to a study published in Environment International by biologist Meiru Wang from Leiden University. Her research on chicken embryos sheds new light on how these tiny plastic particles pose a threat to our health. Disposable cups, plastic bags and packaging material: Plastics exposed to the elements become brittle over time, and start shedding small particles from their surface into nature. These particles can be as tiny as only a few nanometers in size. You can find these nanoplastics everywhere now: in the sea, in the soil, in the food chain.… «And in our blood,» says Wang. «Nanoplastics have even been found in human placentas.» This prompted Wang to think: What happens when those nanoplastics end up in the blood of the embryo? «During an earlier study, we discovered th...
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