New approach uses 'cloaked' proteins to deliver cancer-killing therapeutics into cells

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Schematic of the bioreversible anionic cloaking strategy. Chemical modification of surface-exposed lysines with sulfonated cloaking reagents enables complexation and subsequent delivery of protein cargos with cationic lipids. Following endocytic escape, the reagents are cleaved off via the presence of a self-immolative, redox-sensitive disulfide bond to tracelessly deliver the cargo protein in the cytoplasm of a cell. Credit: ACS Central Science (2024). DOI: 10.1021/acscentsci.4c00071 An interdisciplinary collaboration has designed a way to «cloak» proteins so that they can be captured by lipid nanoparticles, which are akin to tiny bubbles of fat. These bubbles are small enough to sneak their hidden cargo into living cells, where the proteins uncloak and exert their therapeutic effect. The generalizable technique could lead to repurposing thousands of commercial protein products, including antibodies, for biological research and therape
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Amazon deals of the day: M2 MacBook Air, Kindle Scribe, more

Check out Amazon’s best deals of the day for June 15:

Amazon deals of the day at a glance:

macbook air
Beats Studio Pro
NETVUE Birdfy Smart Bird Feeder
kindle scribe

Kick off the weekend with savings at Amazon up to 47% off. On June 15, we’ve got our eyes on a few standout price drops on products from Apple, Amazon, and Netvue. If you’re looking to treat yourself or pick up something for Dad in time for Father’s Day (it’s tomorrow), we’ve already picked out the deals worth your hard-earned cash.

Here are our top picks for the best Amazon deals of the day. And be sure to check out our picks from June 13 and June 14 if you missed them — many of those are still live.

Our top pick

Why we like it

This M2 MacBook Air may have come out in 2022, but it still has all the power you need to be a multitasking beast at work, at home, or on the road. Mashable’s Alex Perry gave this laptop a 4.6/5 rating in his review, where he said that «anyone who’s been rocking an older MacBook for a while should upgrade to this one ASAP.» And it’s an especially great buy today, as it’s back down to its lowest price ever. Is there already an even newer M3 chip on the market? Yes. Do you need to spend hundreds of extra dollars to get it rather than go with the M2? For most users, probably not.

Best earbud deal

Why we like it

For quality sound at a lower price point, the Beats Studio Buds are an excellent choice — and they’re back down to their lowest price ever right now. Mashable’s Alex Perry reviewed the Beats Studio Buds, awarding them a Mashable Choice award and naming them «Apple’s go-to entry-level earbuds» and noting they offer a much better audio experience than the entry-level AirPods. Plus, you’ve got two listening options with active noise cancellation and transparency modes.

Read our full review of the Beats Studio Buds.

Best last-minute Father’s Day deal

Why we like it

It’s simply a rule of nature that all dads eventually grow to love birding. (This rule might even apply to everyone over 35.) If you’re looking for a thoughtful and unique last-minute gift for Father’s Day, this smart bird feeder is a great option. And it will arrive by today or tomorrow with Prime shipping. Set this bird feeder up in your backyard and get an up-close-and-personal view of our flying friends — the included camera will automatically detect motion so you never miss a visitor. Plus, you’ll receive real-time notifications so you can watch the show live from your phone, or race to the window to see for yourself. And you know it’s a great buy as this feeder is back down to its lowest price ever.

Mashable Deals

Best Kindle deal

Amazon Kindle Scribe

Why we like it

It’s finally time to dig into your summer reading list. Treat yourself to a handy companion that holds all of your books and even lets you take notes and doodle in the margins with the Kindle Scribe (16GB) back down to its lowest price ever. This model has the largest display of any Kindle, meaning you can read two pages of a book side by side in landscape mode, as well as the longest battery life of the Kindle suite. Since you never have to recharge the battery-free pen, you can journal and scratch up the book margins to your heart’s content.

None of these deals catching your eye? Check out Amazon’s daily deals for even more savings.

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